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Process of Digestion in Mouth, Stomach , Small and Large Intestine in Human body. MCQ - Practice Questions with Answers

Edited By admin | Updated on Sep 18, 2023 18:34 AM | #NEET

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Process of Digestion: In Mouth and Oesophagus
  • The process of digestion is accomplished by mechanical and chemical processes.
  • The buccal cavity performs the mastication. It is the process of biting and grinding the food with the help of teeth and saliva.
  • Mastication is followed by deglutition. It is the process of swallowing the masticated food (bolus). 
  • The swallowed food is pushed down to the alimentary canal with the help of peristalsis.
  • The gastro-oesophageal sphincter controls the passage of food into the stomach.
  • The saliva secreted into the oral cavity contains electrolytes and enzymes, salivary amylase and lysozyme.
  • The chemical process of digestion is initiated in the oral cavity by the hydrolytic action of the carbohydrate splitting enzyme, the salivary amylase. 
  • About 30 per cent of starch is hydrolysed here by this enzyme (optimum pH 6.8) into a disaccharide – maltose. 
  • Lysozyme present in saliva acts as an antibacterial agent that prevents infections.
     
Process of Digestion: In Stomach
  • The stomach stores food for 4-5 hours. 
  • The food mixes thoroughly with the acidic gastric juice in the stomach by the churning movements of its muscular wall and is called the chyme.
  • The proenzyme pepsinogen, on exposure to hydrochloric acid, gets converted into the active enzyme pepsin, the proteolytic enzymes of the stomach. 
  • Pepsin converts proteins into proteases and peptones (peptides). 
  • The mucus and bicarbonates present in the gastric juice play an important role in lubrication and protection of the mucosal epithelium from excoriation by the highly concentrated hydrochloric acid. 
  • HCl provides the acidic pH (pH 1.8) optimal for pepsin. 
  • Rennin is a proteolytic enzyme found in gastric juice of infants which helps in the digestion of milk proteins. 
  • Small amounts of lipases are also secreted by gastric glands.
     
Process of Digestion: In Small Intestine
  • Various types of movements are generated by the muscularis layer of the small intestine.
  • These movements help in a thorough mixing of the food with various secretions in the intestine and thereby facilitate digestion. 
  • The bile, pancreatic juice and intestinal juice are the secretions released into the small intestine. 
  • Pancreatic juice and bile are released through the hepato-pancreatic duct. 
  • The pancreatic juice contains inactive enzymes – trypsinogen, chymotrypsinogen, procarboxypeptidase, amylases, lipases and nucleases. 
  • Trypsinogen is activated by an enzyme, enterokinase, secreted by the intestinal mucosa into active trypsin, which in turn activates the other enzymes in the pancreatic juice. 
  • The bile released into the duodenum contains bile pigments (bilirubin and biliverdin), bile salts, cholesterol and phospholipids but no enzymes. 
  • Bile helps in emulsification of fats, i.e., breaking down of the fats into very small micelles.
  • Bile also activates lipases.
  • The intestinal mucosal epithelium has goblet cells which secrete mucus. 
  • The secretions of the brush border cells of the mucosa along with the secretions of the goblet cells constitute the intestinal juice or succus entericus. 
  • This juice contains a variety of enzymes like disaccharidases (e.g., maltase), dipeptidases, lipases, nucleosidases, etc.
  • The mucus along with the bicarbonates from the pancreas protects the intestinal mucosa from acid as well as provide an alkaline medium (pH 7.8) for enzymatic activities.
  • Submucosal glands (Brunner’s glands) also help in this.
  • Proteins, proteases and peptones (partially hydrolysed proteins) in the chyme reaching the intestine are acted upon by the proteolytic enzymes of pancreatic juice as given below:

  • Carbohydrates in the chyme are hydrolysed by pancreatic amylase into disaccharides.

  • Fats are broken down by lipases with the help of bile into monoglycerides.

  • Nucleases in the pancreatic juice act on nucleic acids to form nucleotides and nucleosides.

  • The enzymes in the succus entericus act on the end products of the above reactions to form the respective simple absorbable forms. 
  • These final steps in digestion occur near the mucosal epithelial cells of the intestine

Process of Digestion: In Large Intestine
  • The undigested and unabsorbed substances are passed on to the large intestine.
  • No significant digestive activity occurs in the large intestine. 
  • The functions of the large intestine are:
    • absorption of some water, minerals and certain drugs;
    • secretion of mucus which helps in adhering the waste (undigested) particles together and lubricating it for an easy passage
  • The undigested, unabsorbed substances called faeces enters into the caecum of the large intestine through the ileocaecal valve, which prevents the backflow of the faecal matter. 
  • It is temporarily stored in the rectum until defecation.
     

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