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    NEET Re Exam Question Paper 2024 PDF with Solutions: Download Official Paper, Answer Key & Analysis

    Barr Body & Lyon Hypothesis MCQ - Practice Questions with Answers

    Edited By admin | Updated on Sep 18, 2023 18:34 AM | #NEET

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    • 19 Questions around this concept.

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    Barr bodies are found

    Conformational change in DNA by UV  rays is caused due to 
     

    In the following questions, a statement of assertion (A) is followed by a statement of reason (R)

    (1) If both Assertion & Reason are true and the reason is the correct explanation of the assertion, then mark A

    (2) If both Assertion & Reason are true but the reason is not the correct explanation of the assertion, then mark B

     (3) If the Assertion is a true statement but the Reason is false, then mark C

    (4) If both Assertion and Reason are false statements, then mark D

    Assertion: A barr body is a sign that one of the X chromosomes has been inactivated in females. 

    Reason: To provide dosage adjustment between males and females, one of the two X chromosomes in females is randomly selected for inactivation during embryonic development.

     

    What is Dosage Compensation?

    What is a Barr Body?

    Which of the following statements is true regarding the Lyon Hypothesis?

    Which of the following organisms does not exhibit X chromosome inactivation?

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    What is X chromosome inactivation?

    In a female human cell with one Barr body, how many active X chromosomes are present?

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    Both Drosophila and mammals have an XY system of sex determination. Dosage compensation through inactivation of one X chromosome is seen in 

    Concepts Covered - 1

    Dosage Compensation, Barr Body & Lyon Hypothesis
    • In man it has been found that Y-chromosomes are genetically inert in comparison to the X-chromosomes and other chromosomes and only a few genes are present in the human Y-chromosome.
    • As per the chromosomal make-up of human male and female, females contain a higher dose of functional gene containing chromosome than males (Female chromosome numbers = 44 + XX and Male chromosome number = 44 + XY).
    • The geneticists have observed that in some cases, female homozygous for the genes in the X-chromosomes do not express a trait more markedly than do hemizygous males.
    • So, it must be a mechanism of “dosage compensation”, through which the effective dosage of genes of the two sexes is made equal or nearly so.
    • This mechanism of compensating the differential doses of functional sex chromo­somes in male and female human is effected by the inactivation of one X-chromosome in the normal female. 
    • The genetically inactive X- chromosome or condensed X-chromosome is called  heterochromatin or sex-chromatin body or Barr body.
    • Of the two X-chromo­somes in females, which X-chromosome becomes inactive is a matter of chance, but it should be remembered that once an X- chromosome has become inactivated, all cells arising from that cell will keep the same inac­tive X-chromosome.
    • The inactive-X hypothesis or the Lyon’s hypothesis or the Dosage Compensation is widely known from 1961 which states that only one of the two X chromosomes in the homogametic sex is functional while the other condenses and is inactivated. 
    • The X inactivated in some cells would be that from the father, in other cells it would be that from the mother.
    • Hence any tissue in the body of a woman would be a mosaic of cells which would show dominance of all genes having diffusible products.
       

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    Dosage Compensation, Barr Body & Lyon Hypothesis

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