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Chargaff Rule MCQ - NEET Practice Questions with Answers
Edited By admin | Updated on Sep 18, 2023 18:34 AM | #NEET
Quick Facts
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Chargaff Rule is considered one the most difficult concept.
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16 Questions around this concept.
Solve by difficulty
Which one of the following is not applicable to RNA ?
In sea urchin DNA, which is double-stranded, 17% of the bases were shown to be cytosine. The percentages of the other three bases expected to be present in this DNA are:
Concepts Covered - 1
Chargaff Rule
- Erwin Chargaff provided the rule for base equivalence that formed the backbone of the proposition of the structure of DNA given by James Watson and Francis Crick.
- It states that when the DNA from a particular species is subjected to hydrolysis to release its components of purines and pyrimidines, the following would be observed:
- The total amount of adenine released is equal to the total amount of thymine. Similarly, the total amount of cytosine released is equal to the total amount of guanine.
- The base ratio A/T = 1 and C/G = 1.
- So, A/T = C/G = 1, So, A + G = T + C
- Chargaff’s rule allows the determination of percent of all the bases present in the DNA sample if we know the percent of any one of the bases.
- The rule does not apply to single-stranded DNA genomes as well as to mitochondrial genome.
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