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Sickle-cell Anaemia - Practice Questions & MCQ
Edited By admin | Updated on Sep 18, 2023 18:34 AM | #NEET
Quick Facts
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Sickle-cell Anaemia is considered one the most difficult concept.
Concepts Covered - 0
Sickle-cell Anaemia
- It is an autosome-linked recessive trait that can be transmitted from parents to the offsprings when both the partners are the carrier for the gene (heterozygous).
- The disease is controlled by a single pair of alleles, HbA and HbS.
- Out of the three possible genotypes only homozygous individuals for HbS (HbSHbS) show the diseased phenotype.
- It is caused by the substitution of glutamic acid (Glu) by valine (Val) at the sixth position of the beta-globin chain of the hemoglobin molecule.
- The mutant hemoglobin molecule undergoes polymerization under low oxygen tension causing the change in the shape of the RBC from biconcave disc to the elongated sickle-like structure.
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