The Plasma Membrane/Cell Membrane/Plasmalemma
- It is the outermost covering in the animal cells while it is present below the cell wall in fungal and plant cells.
- It is living, thin, delicate, semi-fluid protective covering that surrounds the cytoplasm.
The plasma membrane is composed of the following:
- Proteins (20 - 70%)
- Lipids (20 - 79%)
- Carbohydrates (1 - 5%)
- Enzymes (30 types)
- Water (20%
1. Structure of the plasma membrane
In order to explain the structure of the cell membrane, the following models were proposed:
a) Sandwich/ Trilaminar Model:
- It was given by Hugh Davson and James Danielli in 1935.
- They proposed a sandwich model for the plasma membrane.
- According to them, the plasma membrane was composed of a lipid bilayer that was lined on both its inner and outer surface by a layer of globular proteins.
- They revised their model in the early 1950s to provide reasons for the selective permeability.
- They further modified the sandwich structure to have proteins within the lipid bilayer that acted as a conduit for transport.
b) Unit Membrane Model:
- It was proposed by Robertson in 1959.
- The model proposed that lipids and proteins are present as distinct layers.
- The membrane is asymmetrical because proteins on both sides of the membranes are different. Outer protein is called mucoid protein as it is associated with carbohydrates.
- Inner protein is called non-mucoid protein.
- This model is also known as P-L-L-P model.
- This model holds true for the membranes of organelles.
Drawback of these models:
- Failed to explain the movement of polar compounds across the plasma membrane.
- Considered membrane as a static entity.
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c) Fluid Mosaic Model:
- It was proposed by Singer and Nicolson in 1972.
- With recent modifications, it is the most accepted model for the structure of plasma membrane. This model provides for a core of a lipid bilayer which maintains the fluidity of the plasma membrane.
- The greater the concentration of unsaturated fatty acid residues, the more fluid is the bilayer. The mosaic nature of the plasma membrane is due to its protein content.
- The plasma membrane is quasi fluid structure. The lipids perform the following movements:
rotational movement
lateral diffusion movement
flip-flop movement / transversion movement (rarely shown)
- The proteins perform the following movements:
rotational movement
lateral diffusion movement
- The following table depicts the components of the plasma membrane:
LIPIDS
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PROTEINS
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a) On the basis of ease of extraction
i) integral protein / intrinsic protein -- it is hard to remove; 70% of the total proteins.
ii) Peripheral / extrinsic protein -- it can be easily removed; 30% of the total proteins.
b) On the basis of function
i) Structural protein (forms the backbone)
ii) Carrier protein (facilitates transport)
iii) Enzymatic protein (catalytic in nature)
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CARBOHYDRATES
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